The inhibitor and substrate compete for the same binding site (or the active site) on the enzyme. The inhibitor decreases the enzyme’s capacity to bind the substrate, but this impact may be ...

CHAMPAIGN, Ill. — A new artificial intelligence-powered tool can help researchers determine how well an enzyme fits with a desired target, helping them find the best enzyme and substrate combination ...

Abstract: Enzymes play a critical role in catalyzing biochemical reactions, and accurately predicting their substrate specificity is essential for applications in drug discovery, metabolic engineering ...

Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical ...

Oxidative stress, caused by an imbalance between reactive oxygen species (ROS) and antioxidant defenses, plays a central role in the development of non-communicable diseases (NCDs). These diseases, ...

⭐Aug 26, 2025: We have released the code, model weights and dataset for active site prediction! Check OmniESI_site.zip for more details.😊 ⭐Jul 10, 2025: The source code for OmniESI is released!

Application of enzymes to facilitate lignocellulose biorefinery has long been recognized as the most viable strategy to produce cellulosic biofuels, bio-materials and bio-chemicals. Globally, various ...

New York City (Oct 3, 2024) - Researchers from the Icahn School of Medicine at Mount Sinai have introduced KiNet, an interactive web portal designed to explore kinase-substrate interactions in human ...

As you may know, there are four main types of enzyme inhibition: noncompetitive, uncompetitive, competitive, and mixed inhibition mechanisms. The similarity in their names makes it difficult and ...

Lasso peptides are natural products made by bacteria. Their unusual lasso shape endows them with remarkable stability, protecting them from extreme conditions. In a new study, researchers have ...

1-Naphthylamine (1NA), which is harmful to human and aquatic animals, has been used widely in the manufacturing of dyes, pesticides, and rubber antioxidants. Nevertheless, little is known about its ...