G Protein-Coupled Receptors (GPCRs) in advancing GPCR-targeted therapies, including the use of agonists, antagonists, biased ...

The medicines — known as dopamine agonists — interact with parts of the brain that control movement, helping to ease restless leg syndrome, which is thought to impact one in 10 people in the UK.

Scientists have discovered a naturally occurring molecule that aids appetite control and weight loss so well, it may compete with popular GLP-1 agonists like Ozempic. It's called BRP (BRINP2-related ...

SAN FRANCISCO, Feb. 27, 2025 (GLOBE NEWSWIRE) -- Structure Therapeutics Inc. (NASDAQ: GPCR), a clinical-stage global biopharmaceutical company developing novel oral small molecule therapeutics for ...

"Oral, small molecule GLP-1R agonists have shown meaningful, consistent weight loss in clinical trials over 12-weeks. However, the major limitation within the class continues to be poor ...

an oral small molecule agonist of the parathyroid hormone 1 receptor (PTH1R) aimed at treating hypoparathyroidism. The company decided to discontinue the trial following two unanticipated severe ...

Division of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands ...

Department of Neurology and Stroke Center, The first Affiliated Hospital & Clinical Neuroscience Institute, Key Lab of Basic and Translational Research of Pan-vascular Diseases, Jinan University, ...

However, it is also true that if one scratches the surface, most antagonists are not nearly as villainous as they might initially seem to be. In fact, the truly great antagonists are those who ...