New research identifies the liver protein PTPRD as a key regulator of metabolic liver disease. Reduced levels of PTPRD disrupt glucose and lipid metabolism, promote liver fat accumulation, and impair ...

The addition of tumor-necrosis factor-α (TNF-α) to this treatment approach has changed the situation dramatically. High response rates and limb-salvage rates have been reported in multicenter ...

Cite this: TNF Signaling Inhibition in the CNS: Implications for Normal Brain Function and Neurodegenerative Disease - Medscape - Oct 17, 2008.

One name has caught on in the English-speaking West: “Generation Alpha”. It symbolises a fresh chapter, says Mark McCrindle, the Australian demographer behind it. He canvassed people for ideas ...

The authors demonstrate with convincing evidence the effects of PGE2 on TNF signaling in a well-written manuscript that features methods, data, and analyses in line with current state-of-the-art ...

Tissue necrosis is a devastating complication for many human diseases ... These data reveal a new means by which non-apoptotic Dronc signaling promotes regenerative proliferation in response to ...

The canonical pathway is induced by tumour necrosis factor-α (TNFα), interleukin-1 (IL-1) and many other stimuli, and is dependent on activation of IKKβ. This activation results in the ...

This was accompanied by enhanced ERK signaling, while AKT signaling was not altered ... human IL-1 beta/IL-1F2 and human TNF-alpha Duo Set ELISA kit, R&D Systems, Minneapolis, MN, United States) ...

The Notch signaling pathway regulates developmental cell-fate decisions and has recently also been linked to inflammatory diseases. Although therapies targeting Notch signaling in inflammation in ...