PD Dr. Felix Sommer's team conducted various experiments to investigate the effects of removing the gene responsible for producing the protein in colon cancer cells. If it is no longer present ...

Field cancerization is defined as the preconditioning of an area of epithelium to tumor growth, either as the result of a clonal proliferation of mutant cells through the epithelium without ...

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In contrast, physiological cell shedding allows the renewal of the epithelial monolayer without compromising the barrier function. Here, we investigated the role of live cell extrusion in epithelial ...

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24 Gastroenterology and Liver Unit, Royal Hallamshire Hospital & University of Sheffield, Sheffield, UK Correspondence to David S Sanders, Gastroenterology and Liver Unit, Royal Hallamshire Hospital & ...

After 15-min, the solution was replaced with fresh crypt isolation buffer, and the tissues were shaken for an additional 30 min at 4°C. The tubes were then vigorously shaken to dislodge epithelial ...

In the initial stage, the cancer is in the earliest stage and has not yet exceeded the inner mucosa of the colon or rectum ... these loops were initiated by tumor epithelial cells, fibroblasts, and ...

3Molecular Medicine, Hospital for Sick Children, Toronto, Canada. 4Department of Physiology, University of Toronto, Toronto, Canada 5Department of Biochemistry University of Toronto, Toronto, Canada ...