Celon Pharma’s PDE10A inhibitor has reduced involuntary movements in a phase 2 trial of individuals with Parkinson’s disease. The Polish biotech tested two daily doses of the drug, dubbed CPL ...

Intense moment South Carolina residents run to escape from wildfires spreading to thousands of acres caused by dry conditions and gusty winds. Georgia Ellenwood, the Canadian heptathlete taking ...

Cialis, which is the brand name for the generic medication, tadalafil is part of a class of medications known as phosphodiesterase type 5 inhibitors (PDE5 inhibitors). It works by inhibiting the ...

For example, nimesulide is a weak competitive inhibitor of COX-1 but a potent time-dependent inhibitor of COX-2, whereas celecoxib exhibits slow competitive binding and, at higher concentrations ...

Boehringer Ingelheim has moved one of its top pipeline prospects – oral phosphodiesterase 4B (PDE4B) inhibitor BI 1015550 – into late-stage clinical testing for idiopathic pulmonary fibrosis ...

While not numerous, more pharmacogenetic studies exist in PDE5 inhibitors than in other PH medications and almost exclusively in sildenafil. Most of the pharmacogenetic research carried out with ...

PDE5 inhibitors, such as Cialis and Viagra, work by increasing blood flow to the penis. During sexual stimulation, nitric oxide (NO) is released, leading to an increase in cyclic guanosine ...

This molecule is important for many cell functions. PDE9 is similar to PDE5, the enzyme targeted by Viagra. PDE9 inhibitors are still experimental, meaning they don’t yet have commercial names.

Altitude sickness refers to symptoms of low oxygen, which may happen at elevations at least 8,000 feet above sea level. Symptoms may range from mild to severe. People whose symptoms only worsen while ...

Avanafil is a phosphodiesterase type 5 (PDE5) inhibitor, a class of drugs designed to treat erectile dysfunction. Approved by the FDA in 2012, Stendra works by increasing blood flow to the penis, ...