The researchers outfitted CD4+ T cells with synthetic Notch (synNotch) receptors—highly programmable chimeric receptors that detect target antigens and when bound, prompt the cell to release tailored ...
For example, activation of a synthetic Notch (synNotch) receptor that binds one antigen can trigger the expression of a CAR targeting another antigen. 5 (4) A CAR controlled remotely via drugs and ...
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