If Kittle does miss Sunday's game, he will join star running back Christian McCaffrey, who is currently on the Injured Reserve list with a calf injury and Achilles tendonitis. Wide receiver Deebo Samuel is also missing time following a calf injury he suffered in Week 2. Quarterback Brock Purdy is running low on targets to throw to.

Two key Rams players are improving ahead of Sunday’s game, while the 49ers added three starters to the injury report on Thursday. Notably, Cobie Durant and Kevin Dotson are making progress;

The Rams have their work cut out for them in Week 3 but they have a chance to upset the 49ers if they win these 5 matchups