On Sunday, the 49ers beat Tennessee 37-24, and Aiyuk's replacement, Ricky Pearsall, had six catches for 96 yards. So before they said a word about, they made the statement that they don't need him anymore, although Pearsall injured his ankle and knee during the game and will have an MRI this morning.

SANTA CLARA, Calif. (AP) — The San Francisco 49ers placed receiver Brandon Aiyuk on the reserve/left squad list, making him ineligible to return from a knee injury this season.

The 49ers got a big win against the Titans, and Thomas Morstead did not have to punt once because of the offenses' success.

The San Francisco 49ers resume their quest for the No. 1 seed in the NFC West - yes, seriously - by facing the Tennessee Titans, who are tied for the worst record in the NFL.

Now the San Francisco 49ers look like a team that might be peaking at the right time. Purdy threw three touchdown passes, Christian McCaffrey had two rushing touchdowns and a receiving score, and the 49ers beat the sloppy Arizona Cardinals 41-22 on Sunday.

SANTA CLARA, Calif. -- San Francisco 49ers receiver Ricky Pearsall says he was unsure of his fate after he was shot in the chest during an armed robbery last year near San Francisco's Union Square. "My adrenaline was rushing. I didn't feel, really, much ...

The San Francisco 49ers are trending the right way from a health perspective entering a Week 16 showdown with the Indianapolis Colts.

The San Francisco 49ers are set to part ways with WR Brandon Aiyuk, and head coach Kyle Shanahan didn't mince words when explaining the decision.