A stash of neurotransmitter-packed vesicles hunkers close to the presynaptic membrane so the vesicles can fuse with the membrane and release their cargo as soon as an electrical impulse pulls the ...

They observed hundreds of presynaptic terminals simultaneously ... cytoplasm so that VMAT could actively transport it into the vesicles where it became visible owing to the relatively high ...

By influencing calcium homeostasis, local protein synthesis and the endoplasmic reticulum, a small protein called Rab10 emerges as a crucial cytoplasmic regulator of neuropeptide secretion.

Once considered neurotransmission-related noise, scientists now show that the spontaneous release of presynaptic vesicles is imperative for the maturation of Drosophila synapses. “The paper is very ...

The focus of our research is the study of synaptic transmission, with the emphasis on presynaptic mechanisms. At the synapse, neurotransmitter is rapidly released from small vesicles which are ...

There are two types of removal: Re-uptake – the neurotransmitter is reabsorbed back into the presynaptic neuron and restored inside a vesicle ready to be used again. For example, noradrenaline.