Mammary organoids derived from mouse embryonic stem cells could offer clues into mammary gland developmental origins and help researchers study breast cancer. “When we use embryonic stem cells, they ...

Mammary gland neoplasms in male rats have never been ... Expression of cytokeratin and SMA has been shown in spontaneous and transgenic mouse mammary tumors and in human tumors of mammary origin ...

The work investigates “how aging rewires transcriptomic and epigenomic programs of mouse mammary glands at single-cell resolution.” In doing so, the work establishes, for the first time ...

The study also shows that removal of that gene from mammary glands leads to tumors ... Andrecheck’s new model is a “mouse model” which uses mice to study how cancer spreads.

Specific areas of interest are: The interplay of Wnt and Fgf family members in mammary gland development and breast cancer. Translational regulation as a new therapeutic vulnerability in triple ...

mammary gland, tooth) development and how they are perturbed in diseases such as congenital disorders or tumorigenesis. To reach these goals, we use a combination of genetic mouse models, single cell ...

We examined DSB repair in a Brca1-deficient mouse embryonic stem (ES ... Since these ES cells contain the exon 11 deletion found in mice that conditionally develop mammary gland tumors, the homologous ...