At the interface between these circulating factors and insulin/glucagon secretion are GPCRs, which in islets mediate the effects of many of the circulating factors, such as glucagon-like peptide-1 ...

However, the destruction of β-cells in type 1 diabetes results in the unchecked secretion of somatostatin, inhibiting ...

after intrahepatic islet transplantation, insulin-induced hypoglycemia is associated with normal inhibition of endogenous insulin secretion and either defective or partially restored glucagon ...

Glucagon is secreted to the blood by alpha cells located in the pancreatic islet of Langerhans ... concentrations and in response, glucagon secretion is stimulated to promote endogenous glucose ...

[1] In the presence of elevated glucose concentrations, GLP-1 and GIP increase insulin release and GLP-1 lowers glucagon secretion ... effects on the pancreatic islet cells.

Next, Yeung wanted to determine how this toxin affected glucagon secretion in rodent tissue. She conducted experiments on tissues, such as the rat pancreas and mouse pancreatic islets. Her experiments ...

They were able to show that in type 1 diabetes, these islets are unable to release glucagon when blood sugar is low. This is because the hormone somatostatin is released in greater amounts in type ...

New Delhi: The Subject Expert Committee (SEC) functional under the Central Drug Standard Control Organisation (CDSCO) has ...