In this type of diabetes, the immune system specifically destroys insulin-secreting beta cells in the pancreatic islets — the body's own immune system attacks its own cells (a form of autoimmune ...

In type 1 diabetes, the immune system attacks the beta cells that produce insulin in your pancreas. The attack causes permanent damage and leaves your pancreas unable to produce insulin.

Our perspective about glucose toxicity as it pertains to the pancreatic ß-cell is that the characteristic decreases in insulin synthesis and secretion are caused by decreased insulin gene expression.

In a first, scientists have designed immune cells that protect stem cell transplants from being rejected by the body — and they could someday open the door for a cure for diabetes. The new cells, ...

Increased levels of glucose in the circulation lead to increased glucose uptake into pancreatic beta cells through GLUT2, a glucose transporter. Increased intracellular glucose then leads to ...