Mammalian AMP-activated protein kinase (AMPK) was discovered as a protein kinase that switches off lipid synthesis. The yeast orthologue, the SNF1 complex, was discovered in screens for mutations ...

Furthermore, animals with a muscle-specific deficiency of PanK4 exhibited an increased fat content and impaired fatty acid oxidation within ... key players like mTOR, AMPK, and Akt.

Glucose uptake, fatty acid oxidation, lipolysis and mitochondria ... AMP-activated protein kinase (AMPK) activity and gene expression were determined by quantitative reverse transcriptase-PCR ...