Duke enters Final Four as a worthy favorite, but how can you ignore Houston's experience, defense and grit? Beware the upset!

Since March Madness expanded to 64 teams in 1985, the only other year that all four top-seeded teams from their respective regions earned Final Four spots was 2008. That year, Kansas won a national title with an overtime victory over Memphis.

Madness continued with the men’s Elite Eight and the women’s Sweet 16, where the Duke men rolled past Alabama and Paige Bueckers powered Connecticut.