RB Jordan Mason filled in admirably to start the year, but he was hit with a shoulder injury in Week 6 that he battled until McCaffrey’s return in Week 10. McCaffrey and Mason were both hurt in a Week 13 loss to the Buffalo Bills, which pushed rookie fourth-round pick RB Isaac Guerendo into the starting role.

The 49ers will have to start their fourth different running back this Sunday against the Miami Dolphins. That's because rookie running back Isaac Guerendo is likely to miss Sunday's game with a hamstring injury he suffered this past Thursday night.

San Francisco 49ers running back Isaac Guerendo appeared on Wednesday's injury report due to a hamstring issue sustained during last week's game against

The San Francisco 49ers have been decimated by injuries all year, specifically at the running back position. Christian McCaffrey and Jordan Mason are both on injured reserve, leaving rookie Isaac Guerendo as the top back.

Curious to know about 49ers RB Isaac Guerendo‘s injury? The standout rookie has drawn attention for his breakout performances on the field and his determination to play despite a recent foot injury. From his impressive debut to becoming a key player in the 49ers’ backfield,

Well this isn't good. 49ers rookie Isaac Guerendo is nursing a new injury. Kyle Shanahan revealed Guerendo was held out of Wednesday's practice with a hamstrin

Isaac Guerendo's status for Thursday's game is "up in the air" after suffering a foot sprain in a win vs. the Bears.

“49ers rookie RB Isaac Guerendo plans to play Thursday night vs. the Rams despite his sprained foot that has left him being listed as questionable, per sources. Guerendo insists he ‘feels good,'” Adam Schefter of ESPN reported in a post shared on X, formerly Twitter.

The New Orleans Saints head to Green Bay for a Monday Night Football game against the Packers. The task will be difficult enough with a dome team playing on the Frozen Tundra. Compounding the test, QB Derek Carr will be unavailable.