San Francisco 49ers running back Christian McCaffrey was activated off injured reserve on Saturday and is set to make his NFL season debut on Sunday when the Niners play in Tampa Bay against the Buccaneers.

Yahoo Sports NFL analyst Nate Tice, fantasy analyst Matt Harmon, and NFL writer Charles McDonald discuss whether the return of Christian McCaffrey is enough to get the 49ers back to the Super Bowl. Hear the full conversation on “Football 301” - and subscribe on Apple Podcasts,

We have four teams on bye and a Sunday morning Germany game this week, lightening the main slate injury report to a certain degree. However, there are some very big names both coming and going, including one of the league's top quarterbacks likely heading for season-ending surgery and a top-flight running back expected to make his long-awaited season debut.