Urbino is a comune in the Italian region of Marche, southwest of Pesaro, a World Heritage Site notable for a remarkable historical legacy of indeā¦Urbino is a comune in the Italian region of Marche, southwest of Pesaro, a World Heritage Site notable for a remarkable historical legacy of independent Renaissance culture, especially under the patronage of Federico da Montefeltro, duke of Urbino from 1444 to 1482.